Negative regulation of RIG-I signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of RIG-I signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R13L, DAAM1, and STX2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of RIG-I signaling pathway activity versus PPP1R13L in KIDNEY (Pearson r = -0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PPP1R13L →	-2.620	-0.359	<.001	<.001	3	5
OVARY	DAAM1 →	-1.415	-0.246	.008	.001	2	6
LUNG_NSCLC_LUAD	STX2 →	+1.093	+0.119	.001	.008	3	5
BLOOD_Myeloma	ERI1 →	+1.280	+0.404	.001	.001	3	4
BLOOD_Leukemia	UBE2D3 →	+0.387	+0.119	<.001	.004	2	5
BLOOD_Leukemia	SLC12A9 →	-0.925	-0.156	.008	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039536 vs PPP1R13L — KIDNEY

Explore this scatter interactively →