Regulation of RIG-I signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of RIG-I signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C2orf69, CHAC2, and SDC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of RIG-I signaling pathway activity versus C2orf69 in BLOOD_Myeloma (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	C2orf69 →	+0.669	+0.264	.003	.004	3	5
BLOOD_Myeloma	CHAC2 →	+0.880	+0.307	<.001	<.001	3	4
URINARY_TRACT	SDC1 →	-2.321	-0.358	<.001	.001	3	4
LUNG_NSCLC_LUSC	PRDM1 →	+2.600	+0.270	.002	.006	3	4
STOMACH	CNBP →	+0.552	+0.291	.001	<.001	3	4
BONE	ERAP2 →	+2.687	+0.391	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039535 vs C2orf69 — BLOOD_Myeloma

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