Negative regulation of cytoplasmic pattern recognition receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of cytoplasmic pattern recognition receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GBP2, CD4, and SASH1_S743, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cytoplasmic pattern recognition receptor signaling pathway activity versus GBP2 in COAD (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GBP2 →	+0.432	+0.026	<.001	<.001	3	6
GBM	CD4 →	+0.511	+0.043	.002	<.001	3	6
LSCC	SASH1_S743 →	+0.669	+0.040	<.001	.002	3	5
COAD	CASP4 →	+0.342	+0.020	.001	.006	3	5
GBM	DEF6 →	+0.487	+0.032	.002	.005	3	5
COAD	DOCK2_S1685 →	+0.325	+0.016	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039532 vs GBP2 — COAD

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