Cannabinoid signaling pathway

Across TCGA patient cohorts, RNA activity of the Cannabinoid signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MGLL, PDPK1, and ACAD8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cannabinoid signaling pathway activity versus MGLL in LUAD (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MGLL →	+0.425	+0.118	<.001	<.001	3	6
GBM	PDPK1 →	+0.196	+0.117	.003	.001	3	6
LUAD	ACAD8 →	+0.437	+0.100	.001	<.001	3	6
LUAD	C1orf116 →	+0.824	+0.118	<.001	<.001	3	5
BRCA	CLINT1 →	+0.217	+0.067	<.001	.001	3	5
BRCA	ABLIM3 →	+0.435	+0.065	.006	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038171 vs MGLL — LUAD

Explore this scatter interactively →