Cannabinoid signaling pathway

Across TCGA cell cohorts, RNA activity of the Cannabinoid signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PALM3, SPP1, and PBX1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PALM3 grouped by Cannabinoid signaling pathway-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PALM3 →	+1.982	+1.126	<.001	<.001	3	6
CNS	SPP1 →	-2.037	-0.830	.007	<.001	3	4
CNS	PBX1 →	+1.736	+0.776	.003	.006	3	4
OVARY	TMIE →	+0.888	+1.259	.003	.002	3	4
LUNG_NSCLC_LUAD	CIAO2A →	-0.574	-0.611	<.001	.005	3	4
KIDNEY	RSF1 →	+0.624	+1.284	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PALM3 by Cannabinoid signaling pathway activity — BREAST

Explore this box plot interactively →