Interleukin-3-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Interleukin-3-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHOQ, UQCRC2, and FERMT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RHOQ grouped by Interleukin-3-mediated signaling pathway-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RHOQ →	-0.277	-1.702	.005	<.001	3	4
STOMACH	UQCRC2 →	+0.310	+1.634	.008	.001	3	4
LUNG_NSCLC_LUSC	FERMT2 →	-0.225	-1.616	.007	.001	2	5
BLOOD_Myeloma	LEF1 →	-0.271	-1.346	.009	<.001	3	3
CNS	C6orf223 →	+0.211	+0.290	<.001	.004	3	3
SOFT_TISSUE	METTL14 →	+0.210	+0.124	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RHOQ by Interleukin-3-mediated signaling pathway activity — STOMACH

Explore this box plot interactively →