Interleukin-11-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Interleukin-11-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM150A, TRIM6, and CHD6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM150A grouped by Interleukin-11-mediated signaling pathway-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TMEM150A →	+0.767	+0.909	.003	.004	3	4
BLOOD_Leukemia	TRIM6 →	+1.947	+0.988	.001	.003	3	4
LUNG_SCLC	CHD6 →	-1.336	-1.408	<.001	<.001	3	4
LUNG_SCLC	LMAN2 →	+1.141	+1.322	<.001	.002	3	4
LUNG_SCLC	TOGARAM1 →	-0.750	-1.492	.002	<.001	3	4
SKIN	BIRC2 →	-0.874	-0.777	.007	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM150A by Interleukin-11-mediated signaling pathway activity — PANCREAS

Explore this box plot interactively →