P38MAPK cascade

Across TCGA patient cohorts, RNA activity of the P38MAPK cascade pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WIPF1, WAS, and GPSM3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, P38MAPK cascade activity versus WIPF1 in OV (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WIPF1 →	+0.473	+0.040	<.001	<.001	3	10
LSCC	WAS →	+0.524	+0.080	<.001	<.001	3	9
GBM	GPSM3 →	+0.502	+0.056	<.001	<.001	3	9
LSCC	LCP2 →	+0.548	+0.071	<.001	<.001	3	9
LSCC	ARHGAP25 →	+0.627	+0.074	<.001	<.001	3	9
GBM	TNFAIP8L2 →	+0.749	+0.064	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038066 vs WIPF1 — OV

Explore this scatter interactively →