P38MAPK cascade

Across TCGA pan-cancer cohorts, RNA activity of the P38MAPK cascade pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 57 member genes.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher P38MAPK cascade pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and HNSC, show the opposite pattern, with higher activity associated with better survival.

SKCM, ACC, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.416	0.289	<.001	101	view →
ACC	OS	Median	All	0.422	0.783	<.001	100	view →
HNSC	DFS	Tertile	II,III,IV	0.809	0.606	<.001	71	view →
MESO	OS	Median	II,III,IV	0.193	0.384	.004	42	view →
UVM	DFS	Quartile	II,III,IV	0.277	0.626	.002	40	view →
LGG	DFS	Median	All	0.265	0.474	<.001	32	view →
LUAD	DFS	Median	II,III,IV	0.608	0.314	.001	31	view →
ESCA	DFS	Median	III,IV	0.441	0.211	<.001	29	view →
KIRC	DFS	Tertile	All	0.523	0.672	.004	27	view →
BRCA	OS	Quartile	All	0.572	0.487	.003	19	view →
TGCT	OS	Tertile	All	0.927	0.995	.039	18	view →
THCA	DFS	Median	III,IV	0.742	0.872	.024	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0038066–SKCM (OS)

Open the SKCM breakdown →