P38MAPK cascade

Across TCGA patient cohorts, RNA activity of the P38MAPK cascade pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM20A, LILRB3, and PRAM1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, P38MAPK cascade activity versus FAM20A in UCEC (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAM20A →	+0.931	+0.491	<.001	.002	3	6
UCEC	LILRB3 →	+0.695	+0.533	<.001	.005	3	6
BRCA	PRAM1 →	+0.419	+0.455	.001	.009	2	7
COAD	ITGAX →	+0.658	+0.209	.002	.005	3	6
COAD	OSCAR →	+0.729	+0.293	<.001	<.001	3	6
OV	MT2A →	+0.955	+0.670	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038066 vs FAM20A — UCEC

Explore this scatter interactively →