Apolipoprotein A-I-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Apolipoprotein A-I-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPP1, FCGR2A, and RFC4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apolipoprotein A-I-mediated signaling pathway activity versus SPP1 in GBM (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SPP1 →	+0.785	+0.169	.001	.005	3	5
UCEC	FCGR2A →	+0.606	+0.139	.002	.006	3	4
OV	RFC4 →	+0.595	+0.130	.001	.007	3	4
CCRCC	LHFPL2 →	+0.500	+0.123	.001	<.001	3	4
GBM	CARF →	-0.219	-0.162	.004	.008	3	4
GBM	PBX1 →	-0.417	-0.220	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038027 vs SPP1 — GBM

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