Apolipoprotein A-I-mediated signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Apolipoprotein A-I-mediated signaling pathway pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher Apolipoprotein A-I-mediated signaling pathway pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and BLCA, show the opposite pattern, with higher activity associated with better survival.

ESCA, BLCA, and PRAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	III,IV	0.727	0.416	<.001	44	view →
BLCA	OS	Median	All	0.510	0.353	.002	30	view →
PRAD	OS	Quartile	All	0.716	1.000	<.001	26	view →
LIHC	OS	Median	All	0.704	0.843	.006	24	view →
SARC	OS	Median	All	0.858	0.596	<.001	19	view →
ACC	OS	Median	II,III,IV	0.785	0.459	.012	16	view →
LGG	OS	Tertile	All	0.940	0.878	.009	16	view →
MESO	OS	Quartile	III,IV	0.282	0.752	.004	15	view →
THYM	OS	Median	All	0.773	1.000	.009	14	view →
UCS	OS	Median	IV	0.224	0.694	.004	12	view →
UCEC	OS	Quartile	IV	0.226	0.713	.009	12	view →
SCLC	DFS	Quartile	II,III,IV	0.375	0.701	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0038027–ESCA (OS)

Open the ESCA breakdown →