Reelin-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Reelin-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RABL6, NT5C, and BMPR1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reelin-mediated signaling pathway activity versus RABL6 in LARGE_INTESTINE (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RABL6 →	-0.393	-0.817	.002	<.001	3	4
KIDNEY	NT5C →	+0.499	+0.919	.002	.004	3	3
SKIN	BMPR1B →	+1.096	+0.988	<.001	.001	3	3
CNS	ZNF212 →	+0.475	+1.002	.002	<.001	3	3
CNS	SMYD4 →	+0.629	+0.910	.005	.001	3	3
CNS	ZNF138 →	+0.524	+0.874	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038026 vs RABL6 — LARGE_INTESTINE

Explore this scatter interactively →