Netrin-activated signaling pathway

Across TCGA patient cohorts, RNA activity of the Netrin-activated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCN5, LRRC15, and FCGR2C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Netrin-activated signaling pathway activity versus CCN5 in HNSC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CCN5 →	-0.849	-0.487	.001	.003	2	5
LUAD	LRRC15 →	-1.149	-0.674	<.001	.001	3	4
LUAD	FCGR2C →	-0.616	-0.654	.001	.001	3	4
LUAD	OMD →	-0.685	-0.770	<.001	<.001	3	3
PDAC	CTSD →	-0.368	-0.519	<.001	<.001	3	3
PDAC	CEBPB →	-0.462	-0.446	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038007 vs CCN5 — HNSC

Explore this scatter interactively →