Netrin-activated signaling pathway

Across TCGA cell cohorts, RNA activity of the Netrin-activated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBB3, MSANTD3, and BCL11B, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Netrin-activated signaling pathway activity versus TUBB3 in BLOOD_Lymphoma (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TUBB3 →	+3.616	+0.927	<.001	<.001	3	16
URINARY_TRACT	MSANTD3 →	+1.030	+0.160	.002	.002	3	8
BLOOD_Lymphoma	BCL11B →	-0.842	-0.627	<.001	<.001	3	8
URINARY_TRACT	TUBB2A →	+2.001	+0.199	<.001	<.001	3	8
PANCREAS	TUBA1C →	+0.669	+0.133	<.001	<.001	3	7
BLOOD_Leukemia	GLRX3 →	+0.493	+0.799	.002	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038007 vs TUBB3 — BLOOD_Lymphoma

Explore this scatter interactively →