Netrin-activated signaling pathway

Across TCGA cell cohorts, RNA activity of the Netrin-activated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF16, TUBB3, and CCT6A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Netrin-activated signaling pathway activity versus KLF16 in URINARY_TRACT (Pearson r = 0.89).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	KLF16 →	+1.050	+1.202	.003	.008	3	7
LUNG_SCLC	TUBB3 →	+1.840	+0.445	<.001	.003	3	5
KIDNEY	CCT6A →	+0.874	+1.639	.007	.006	3	5
PANCREAS	RAB8A →	+0.895	+1.323	<.001	.002	3	5
SOFT_TISSUE	POP1 →	+1.022	+1.892	.007	<.001	3	4
LUNG_NSCLC_LUSC	METTL21A →	+1.780	+1.623	.007	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038007 vs KLF16 — URINARY_TRACT

Explore this scatter interactively →