Calcium import into the mitochondrion

Across TCGA patient cohorts, RNA activity of the Calcium import into the mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SETBP1, NRXN3, and ASPA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium import into the mitochondrion activity versus SETBP1 in LUAD (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SETBP1 →	-0.879	-0.134	<.001	.001	3	5
LSCC	NRXN3 →	-0.565	-0.125	.003	<.001	3	4
UCEC	ASPA →	-0.550	-0.184	.001	.001	3	4
COAD	STAR →	-0.073	-0.128	<.001	<.001	3	4
PDAC	ADPRM →	-0.283	-0.154	<.001	.001	3	4
GBM	GLRX3P2 →	-0.397	-0.139	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036444 vs SETBP1 — LUAD

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