Calcium import into the mitochondrion

Across TCGA pan-cancer cohorts, RNA activity of the Calcium import into the mitochondrion pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 12 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Calcium import into the mitochondrion pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and READ, show the opposite pattern, with higher activity associated with better survival.

ACC, KICH, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Quartile	All	0.320	0.744	<.001	80	view →
KICH	OS	Tertile	All	0.810	0.976	.002	60	view →
SKCM	OS	Tertile	All	0.896	0.673	.001	50	view →
KIRC	OS	Tertile	All	0.562	0.724	.001	42	view →
LIHC	OS	Quartile	All	0.541	0.754	<.001	40	view →
UCEC	DFS	Quartile	All	0.751	0.900	<.001	38	view →
MESO	OS	Quartile	All	0.240	0.502	.001	33	view →
READ	DFS	Median	II,III,IV	0.842	0.559	.002	30	view →
BRCA	OS	Median	II,III,IV	0.970	0.946	.013	28	view →
UVM	DFS	Tertile	III,IV	0.281	0.876	.002	21	view →
SCLC	DFS	Tertile	III,IV	0.256	0.728	.006	21	view →
LAML	DFS	Tertile	All	0.674	0.331	.005	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0036444–ACC (DFS)

Open the ACC breakdown →