Maintenance of lens transparency

Across TCGA patient cohorts, RNA activity of the Maintenance of lens transparency pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DTX3, MAP1A, and RAB23, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of lens transparency activity versus DTX3 in GBM (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DTX3 →	+0.390	+0.062	.002	.002	3	5
GBM	MAP1A →	+0.363	+0.055	<.001	.001	3	5
OV	RAB23 →	+0.507	+0.066	.006	.005	3	5
GBM	MAP1A_S667 →	+0.344	+0.046	.001	.008	3	5
HNSC	COG7_S506 →	-0.938	-0.087	<.001	.001	3	4
GBM	REPS2_S493 →	+0.819	+0.092	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036438 vs DTX3 — GBM

Explore this scatter interactively →