Maintenance of lens transparency

Across TCGA patient cohorts, RNA activity of the Maintenance of lens transparency pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STK39, PALD1, and SLC51B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of lens transparency activity versus STK39 in CCRCC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	STK39 →	+1.040	+0.740	<.001	<.001	3	4
BRCA	PALD1 →	+0.465	+0.549	.006	<.001	3	3
CCRCC	SLC51B →	+0.711	+0.530	<.001	.002	3	3
CCRCC	FAM136BP →	+0.187	+0.438	.006	.009	3	3
PDAC	NHP2P1 →	+0.309	+0.603	.008	.009	3	3
PDAC	OR2W6P →	-0.442	-0.624	.007	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036438 vs STK39 — CCRCC

Explore this scatter interactively →