Maintenance of lens transparency

Across TCGA cell cohorts, RNA activity of the Maintenance of lens transparency pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FHDC1, N6AMT1, and MRNIP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FHDC1 grouped by Maintenance of lens transparency-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	FHDC1 →	+1.362	+0.985	.001	.005	3	5
SOFT_TISSUE	N6AMT1 →	-0.858	-1.442	<.001	.006	3	5
CNS	MRNIP →	-0.613	-1.132	.001	<.001	3	4
URINARY_TRACT	IL11 →	-3.346	-1.981	.006	<.001	3	4
LARGE_INTESTINE	ATP8A1 →	+1.340	+0.819	<.001	.002	3	4
KIDNEY	ATP6V1H →	-0.772	-1.062	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FHDC1 by Maintenance of lens transparency activity — KIDNEY

Explore this box plot interactively →