Maintenance of lens transparency

Across TCGA cell cohorts, RNA activity of the Maintenance of lens transparency pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH1A1, DOK7, and MAN2B1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of lens transparency activity versus ALDH1A1 in LUNG_SCLC (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ALDH1A1 →	+6.050	+0.381	<.001	<.001	3	4
KIDNEY	DOK7 →	-1.760	-0.202	.005	.003	3	3
PANCREAS	MAN2B1 →	-0.797	-0.403	.001	.002	3	3
PANCREAS	CAPN5 →	+2.723	+0.496	.004	.005	3	3
KIDNEY	FAM169A →	-0.756	-0.283	<.001	.001	3	3
STOMACH	CMC2 →	+1.427	+0.447	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036438 vs ALDH1A1 — LUNG_SCLC

Explore this scatter interactively →