Fas signaling pathway

Across TCGA cell cohorts, RNA activity of the Fas signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF599, SCUBE3, and TTC26, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF599 grouped by Fas signaling pathway-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF599 →	-0.835	-1.535	.001	<.001	3	4
SKIN	SCUBE3 →	-1.337	-0.683	.009	.005	3	4
STOMACH	TTC26 →	-0.747	-1.226	<.001	.006	3	3
STOMACH	CYP4F12 →	+2.397	+0.907	.001	.005	3	3
KIDNEY	ROR1 →	-1.233	-0.988	.001	.009	3	3
PANCREAS	ENAH →	-1.304	-0.954	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF599 by Fas signaling pathway activity — LUNG_SCLC

Explore this box plot interactively →