Fas signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Fas signaling pathway pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Fas signaling pathway pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and MESO, show the opposite pattern, with higher activity associated with better survival.

KIRC, KIRP, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.553	0.700	<.001	100	view →
KIRP	DFS	Median	All	0.443	0.699	<.001	72	view →
LGG	OS	Median	All	0.742	0.863	<.001	36	view →
SKCM	OS	Tertile	All	0.391	0.236	<.001	28	view →
UCEC	DFS	Median	All	0.590	0.687	.014	26	view →
MESO	OS	Tertile	IV	0.872	0.371	.014	19	view →
ACC	DFS	Median	All	0.783	0.563	.005	19	view →
READ	DFS	Tertile	All	0.871	0.257	.010	13	view →
ESCA	OS	Tertile	IV	0.219	0.916	.024	12	view →
BLCA	DFS	Tertile	IV	0.407	0.593	.013	11	view →
CHOL	DFS	Quartile	II,III,IV	0.697	0.219	.013	9	view →
KICH	OS	Median	II,III,IV	0.800	0.967	.008	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0036337–KIRC (OS)

Open the KIRC breakdown →