7-methylguanosine cap hypermethylation

Across TCGA patient cohorts, RNA activity of the 7-methylguanosine cap hypermethylation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC2, TOP2A_S1247, and TOP2A_S1377, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 7-methylguanosine cap hypermethylation activity versus RFC2 in LSCC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC2 →	+0.391	+0.073	<.001	<.001	3	8
CCRCC	TOP2A_S1247 →	+1.089	+0.044	<.001	<.001	3	8
CCRCC	TOP2A_S1377 →	+1.204	+0.051	.002	<.001	3	8
GBM	UBTF_S484 →	+0.910	+0.068	<.001	<.001	3	8
UCEC	SMC2 →	+0.613	+0.096	<.001	.008	3	8
BRCA	SMC4 →	+0.651	+0.053	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036261 vs RFC2 — LSCC

Explore this scatter interactively →