Granulocyte activation

Across TCGA cell cohorts, RNA activity of the Granulocyte activation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST3GAL1, SDC2, and FAM218A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ST3GAL1 grouped by Granulocyte activation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ST3GAL1 →	+1.102	+0.348	.002	.002	3	4
OVARY	SDC2 →	-3.284	-0.358	.001	<.001	3	4
BONE	FAM218A →	-0.631	-0.324	<.001	<.001	3	4
SOFT_TISSUE	ROM1 →	-0.872	-0.291	.002	.001	3	3
OVARY	NUDT9 →	-0.950	-0.360	<.001	<.001	3	3
SOFT_TISSUE	C15orf65 →	-1.067	-0.244	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ST3GAL1 by Granulocyte activation activity — CNS

Explore this box plot interactively →