Granulocyte activation

Across TCGA pan-cancer cohorts, RNA activity of the Granulocyte activation pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 50 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Granulocyte activation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and ESCA, show the opposite pattern, with higher activity associated with better survival.

UVM, SKCM, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.373	0.813	<.001	97	view →
SKCM	OS	Median	All	0.438	0.271	<.001	61	view →
LGG	DFS	Median	All	0.276	0.483	<.001	47	view →
DLBC	OS	Median	All	0.507	1.000	.004	32	view →
ESCA	DFS	Median	III,IV	0.491	0.234	.005	29	view →
GBM	DFS	Median	All	0.184	0.386	.002	27	view →
MESO	OS	Tertile	All	0.683	0.432	.001	27	view →
LAML	DFS	Quartile	All	0.171	0.663	<.001	22	view →
KIRC	OS	Tertile	All	0.524	0.718	.004	22	view →
ACC	DFS	Median	All	0.771	0.549	.007	20	view →
STAD	DFS	Quartile	III,IV	0.173	0.522	.012	15	view →
SARC	OS	Median	All	0.612	0.439	.007	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0036230–UVM (OS)

Open the UVM breakdown →