Granulocyte activation

Across TCGA cell cohorts, RNA activity of the Granulocyte activation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, EMP1, and RASAL2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Granulocyte activation activity versus ANXA1 in BREAST (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ANXA1 →	+3.884	+0.732	<.001	.001	3	8
BREAST	EMP1 →	+2.789	+0.522	<.001	.001	3	6
LARGE_INTESTINE	RASAL2 →	+0.654	+0.175	.006	.006	3	6
CNS	PVR →	+0.815	+0.211	.005	.007	3	6
BLOOD_Leukemia	ALDH3B1 →	+2.652	+0.718	<.001	<.001	3	5
LUNG_NSCLC_LUAD	TRAF4 →	-0.866	-0.194	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036230 vs ANXA1 — BREAST

Explore this scatter interactively →