Limb joint morphogenesis

Across TCGA patient cohorts, RNA activity of the Limb joint morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MDH1, FNDC3B, and EXT1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Limb joint morphogenesis activity versus MDH1 in PDAC (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MDH1 →	-0.191	-0.046	<.001	.001	3	7
LSCC	FNDC3B →	+0.268	+0.046	.004	.009	3	6
LSCC	EXT1 →	+0.374	+0.071	<.001	<.001	3	5
OV	EXT2 →	+0.294	+0.057	<.001	.004	3	5
LSCC	MMP14 →	+0.320	+0.050	.004	.005	3	5
HNSC	PLOD1 →	+0.275	+0.058	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036022 vs MDH1 — PDAC

Explore this scatter interactively →