Limb joint morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Limb joint morphogenesis pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Limb joint morphogenesis pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and READ, show the opposite pattern, with higher activity associated with better survival.

KIRP, UVM, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.516	0.826	.001	65	view →
UVM	DFS	Tertile	II,III,IV	0.414	0.741	.001	59	view →
BRCA	OS	Tertile	All	0.951	0.972	.015	17	view →
UCS	DFS	Tertile	II,III,IV	0.569	0.219	.020	16	view →
READ	DFS	Median	III,IV	0.827	0.669	.017	15	view →
PCPG	OS	Median	All	0.931	1.000	.011	11	view →
LUAD	OS	Median	All	0.761	0.883	<.001	11	view →
MESO	OS	Tertile	III,IV	0.871	0.349	.017	9	view →
ACC	DFS	Tertile	II,III,IV	0.480	0.772	.013	9	view →
LUSC	DFS	Median	IV	0.827	0.134	.024	6	view →
LAML	DFS	Quartile	All	0.271	0.534	.036	4	view →
BLCA	DFS	Quartile	III,IV	0.374	0.642	.022	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0036022–KIRP (OS)

Open the KIRP breakdown →