Limb joint morphogenesis

Across TCGA patient cohorts, RNA activity of the Limb joint morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPS9-AS1, FCHO1, and EEF2K, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Limb joint morphogenesis activity versus MRPS9-AS1 in UCEC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPS9-AS1 →	+0.504	+0.185	<.001	<.001	3	4
COAD	FCHO1 →	-0.421	-0.346	.003	.003	3	4
CCRCC	EEF2K →	+0.337	+0.379	.001	.002	3	3
CCRCC	CRTC1 →	+0.208	+0.270	.005	.002	3	3
UCEC	GNL3L →	+0.361	+0.120	.003	.002	3	3
CCRCC	PRCC →	+0.308	+0.351	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036022 vs MRPS9-AS1 — UCEC

Explore this scatter interactively →