Limb joint morphogenesis

Across TCGA cell cohorts, RNA activity of the Limb joint morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTNNB1, OSR1, and COL3A1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTNNB1 grouped by Limb joint morphogenesis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CTNNB1 →	-1.781	-1.166	<.001	<.001	3	16
KIDNEY	OSR1 →	-0.371	-1.616	.002	<.001	3	10
KIDNEY	COL3A1 →	-0.184	-1.523	<.001	<.001	3	5
BONE	ALOX15B →	+0.497	+1.925	.004	<.001	3	4
KIDNEY	NT5DC3 →	-0.202	-1.804	.007	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	CSNK1A1 →	-0.356	-1.561	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTNNB1 by Limb joint morphogenesis activity — LARGE_INTESTINE

Explore this box plot interactively →