Limb joint morphogenesis

Across TCGA cell cohorts, RNA activity of the Limb joint morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNK6, DNAJC18, and ACADS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNK6 grouped by Limb joint morphogenesis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	KCNK6 →	+1.884	+1.168	<.001	.005	3	5
LIVER	DNAJC18 →	-2.480	-1.933	.007	.002	3	5
LARGE_INTESTINE	ACADS →	+0.904	+1.016	.007	.004	3	5
BLOOD_Myeloma	SCML2 →	-2.930	-1.168	<.001	.005	3	4
CNS	EBP →	+0.936	+0.985	.008	.003	3	4
LIVER	BBS12 →	-0.830	-1.892	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNK6 by Limb joint morphogenesis activity — BLOOD_Myeloma

Explore this box plot interactively →