Dorsal aorta development

Across TCGA patient cohorts, RNA activity of the Dorsal aorta development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYNPO2, CXCL12, and PGK1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dorsal aorta development activity versus SYNPO2 in CCRCC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SYNPO2 →	+1.096	+0.577	<.001	.004	3	6
UCEC	CXCL12 →	+0.757	+0.411	.003	.004	3	5
PDAC	PGK1 →	-0.496	-0.613	.002	.004	3	5
UCEC	SLC16A2 →	+0.899	+0.629	<.001	.003	2	5
LSCC	NGFR →	+1.713	+0.967	<.001	<.001	3	4
GBM	TSHZ3 →	+0.472	+0.577	.009	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035907 vs SYNPO2 — CCRCC

Explore this scatter interactively →