Dorsal aorta development

Across TCGA cell cohorts, RNA activity of the Dorsal aorta development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FUT2, CAAP1, and SUN2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dorsal aorta development activity versus FUT2 in SKIN (Pearson r = -0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FUT2 →	-0.397	-2.005	.005	<.001	3	2
BONE	CAAP1 →	-0.868	-0.317	.005	.007	3	2
SKIN	SUN2 →	+0.899	+2.118	.002	<.001	3	1
SKIN	PLTP →	-2.806	-1.687	.005	<.001	3	1
SKIN	URI1 →	-0.642	-2.111	<.001	<.001	3	1
SKIN	PFN1 →	+0.721	+1.756	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035907 vs FUT2 — SKIN

Explore this scatter interactively →