Response to immobilization stress

Across TCGA patient cohorts, RNA activity of the Response to immobilization stress pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PYY2, SEMA3C, and KLHL24, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to immobilization stress activity versus PYY2 in HNSC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PYY2 →	+1.173	+0.451	.001	.006	3	3
UCEC	SEMA3C →	+0.660	+0.319	.005	.003	3	3
LSCC	KLHL24 →	+0.443	+0.096	.007	.006	3	3
COAD	DSTN →	+0.362	+0.606	.001	<.001	3	3
COAD	GAMT →	+0.592	+0.612	<.001	.001	3	3
COAD	PSD3 →	+0.421	+0.737	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035902 vs PYY2 — HNSC

Explore this scatter interactively →