Response to immobilization stress

Across TCGA pan-cancer cohorts, RNA activity of the Response to immobilization stress pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 24 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Response to immobilization stress pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and CESC, show the opposite pattern, with higher activity associated with better survival.

HNSC, CESC, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.791	0.596	<.001	99	view →
CESC	OS	Median	All	0.880	0.721	<.001	54	view →
MESO	OS	Quartile	All	0.720	0.336	<.001	49	view →
ACC	OS	Quartile	II,III,IV	1.000	0.688	.003	41	view →
LIHC	OS	Median	All	0.582	0.443	.004	37	view →
LUSC	OS	Median	All	0.822	0.736	.007	34	view →
LGG	OS	Median	All	0.740	0.858	<.001	30	view →
SARC	OS	Tertile	All	0.919	0.752	<.001	27	view →
SKCM	OS	Quartile	All	0.853	0.709	<.001	25	view →
BRCA	OS	Quartile	III,IV	0.959	0.815	.003	23	view →
ESCA	DFS	Tertile	All	0.269	0.880	.004	21	view →
BLCA	OS	Quartile	III,IV	0.758	0.588	.004	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0035902–HNSC (OS)

Open the HNSC breakdown →