Protein K11-linked deubiquitination

Across TCGA cell cohorts, RNA activity of the Protein K11-linked deubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CUTC, HMGXB4, and CXADR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K11-linked deubiquitination activity versus CUTC in OVARY (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CUTC →	+0.689	+0.580	.005	.005	2	5
BREAST	HMGXB4 →	-0.650	-0.533	.001	.004	3	4
OVARY	CXADR →	-2.917	-0.544	.001	<.001	3	3
BONE	APPL1 →	-1.283	-0.426	.009	.004	3	3
KIDNEY	LRRC45 →	+0.950	+0.531	.005	.006	3	3
OVARY	FBH1 →	+0.927	+0.488	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035871 vs CUTC — OVARY

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