Protein K11-linked deubiquitination

Across TCGA pan-cancer cohorts, RNA activity of the Protein K11-linked deubiquitination pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 10 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Protein K11-linked deubiquitination pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and THCA, show the opposite pattern, with higher activity associated with better survival.

MESO, LIHC, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.426	0.679	<.001	78	view →
LIHC	DFS	Median	All	0.444	0.630	<.001	50	view →
ACC	DFS	Median	All	0.200	0.647	<.001	42	view →
KIRC	DFS	Quartile	All	0.932	0.785	.003	41	view →
CESC	DFS	Quartile	All	0.603	0.817	.003	38	view →
PAAD	OS	Median	II,III,IV	0.295	0.610	.002	32	view →
SCLC	DFS	Median	All	0.560	0.944	.003	21	view →
THCA	OS	Tertile	All	1.000	0.915	.013	17	view →
HNSC	OS	Tertile	III,IV	0.521	0.779	.018	12	view →
ESCA	OS	Median	III,IV	0.535	0.323	.027	11	view →
DLBC	DFS	Quartile	All	0.557	0.930	.018	9	view →
SARC	OS	Quartile	All	0.663	0.824	.010	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0035871–MESO (OS)

Open the MESO breakdown →