Photoreceptor cell outer segment organization

Across TCGA patient cohorts, RNA activity of the Photoreceptor cell outer segment organization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UPP1, CAMLG, and NDUFB5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Photoreceptor cell outer segment organization activity versus UPP1 in GBM (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UPP1 →	-0.633	-0.077	.008	<.001	3	4
BRCA	CAMLG →	+0.340	+0.036	<.001	.001	3	4
PDAC	NDUFB5 →	+0.422	+0.035	.002	.006	2	5
PDAC	OMA1 →	+0.618	+0.043	<.001	.001	3	4
LSCC	CARD11_S925 →	-0.847	-0.058	.001	<.001	3	4
LSCC	EIF4G3 →	+0.178	+0.045	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035845 vs UPP1 — GBM

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