Regulation of renal sodium excretion

Across TCGA cell cohorts, RNA activity of the Regulation of renal sodium excretion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGT, NACA, and NPPB, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of renal sodium excretion activity versus AGT in LUNG_SCLC (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AGT →	+4.208	+1.566	<.001	<.001	3	10
STOMACH	NACA →	-0.586	-0.869	.001	.002	3	7
LUNG_NSCLC_LUSC	NPPB →	+4.828	+1.754	.004	.005	3	7
BONE	RCC1 →	-0.983	-0.764	.006	.005	3	7
OESOPHAGUS	SERPINB9 →	+1.291	+0.145	.003	.005	3	6
LUNG_NSCLC_LUAD	SPX →	+2.289	+1.037	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035813 vs AGT — LUNG_SCLC

Explore this scatter interactively →