Platelet-derived growth factor receptor-beta signaling pathway

Across TCGA patient cohorts, RNA activity of the Platelet-derived growth factor receptor-beta signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THBS1, NID2, and SERPINH1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Platelet-derived growth factor receptor-beta signaling pathway activity versus THBS1 in COAD (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	THBS1 →	+1.247	+0.083	<.001	<.001	3	10
COAD	NID2 →	+0.552	+0.091	<.001	<.001	3	10
OV	SERPINH1 →	+0.546	+0.085	<.001	<.001	3	9
OV	TLN1_S2162 →	+0.885	+0.083	<.001	.001	3	9
GBM	COL5A1 →	+0.892	+0.066	<.001	.001	3	9
OV	CRTAP →	+0.633	+0.102	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035791 vs THBS1 — COAD

Explore this scatter interactively →