Platelet-derived growth factor receptor-beta signaling pathway

Across TCGA patient cohorts, RNA activity of the Platelet-derived growth factor receptor-beta signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPD1L, ATP8B1, and CTSB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Platelet-derived growth factor receptor-beta signaling pathway activity versus GPD1L in BRCA (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GPD1L →	-0.845	-0.173	.002	.004	3	4
BRCA	ATP8B1 →	-0.786	-0.167	.002	.002	3	4
OV	CTSB →	+0.524	+0.137	.006	.008	3	4
HNSC	SOX13 →	-0.808	-0.173	<.001	<.001	3	4
LSCC	SUGCT →	+0.825	+0.225	<.001	<.001	3	4
LSCC	SNHG1 →	-0.481	-0.147	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035791 vs GPD1L — BRCA

Explore this scatter interactively →