Platelet-derived growth factor receptor-beta signaling pathway

Across TCGA cell cohorts, RNA activity of the Platelet-derived growth factor receptor-beta signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALD1, YARS1, and RGL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CALD1 grouped by Platelet-derived growth factor receptor-beta signaling pathway-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CALD1 →	-2.706	-0.741	.004	.002	3	4
KIDNEY	YARS1 →	-0.816	-1.474	.004	<.001	3	4
BREAST	RGL1 →	-1.141	-0.753	.004	.004	3	4
BREAST	C20orf27 →	-1.190	-0.878	<.001	<.001	3	3
BREAST	ABHD11 →	+1.322	+0.757	<.001	<.001	3	3
BREAST	GDF15 →	+2.850	+0.728	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CALD1 by Platelet-derived growth factor receptor-beta signaling pathway activity — BREAST

Explore this box plot interactively →