Platelet-derived growth factor receptor-beta signaling pathway

Across TCGA cell cohorts, RNA activity of the Platelet-derived growth factor receptor-beta signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDGFA, CLASP2, and ABL1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Platelet-derived growth factor receptor-beta signaling pathway activity versus PDGFA in STOMACH (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PDGFA →	+1.995	+0.150	<.001	<.001	3	11
LUNG_SCLC	CLASP2 →	+1.146	+0.235	<.001	<.001	3	11
KIDNEY	ABL1 →	+1.269	+0.177	<.001	<.001	3	8
BLOOD_Lymphoma	JAZF1 →	+1.708	+0.171	<.001	<.001	3	8
KIDNEY	FAM126A →	+1.179	+0.140	.001	.002	3	8
SOFT_TISSUE	KLF12 →	+1.018	+0.158	.009	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035791 vs PDGFA — STOMACH

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