TRIF-dependent toll-like receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the TRIF-dependent toll-like receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANAPC7, MCF2L-AS1, and CAMK2N2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, TRIF-dependent toll-like receptor signaling pathway activity versus ANAPC7 in GBM (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ANAPC7 →	-0.295	-0.159	.005	.004	3	4
GBM	MCF2L-AS1 →	-0.536	-0.140	.003	.003	3	4
LSCC	CAMK2N2 →	-0.670	-0.187	.001	.005	3	4
LSCC	MAP4K1 →	+0.425	+0.172	<.001	.001	3	3
GBM	CSRNP2 →	-0.206	-0.135	.007	.001	3	3
GBM	CERS5 →	-0.315	-0.143	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035666 vs ANAPC7 — GBM

Explore this scatter interactively →