TRIF-dependent toll-like receptor signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the TRIF-dependent toll-like receptor signaling pathway pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher TRIF-dependent toll-like receptor signaling pathway pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and HNSC, show the opposite pattern, with higher activity associated with better survival.

SKCM, HNSC, and LAML are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.440	0.246	<.001	103	view →
HNSC	DFS	Quartile	III,IV	0.764	0.584	.006	40	view →
LAML	DFS	Tertile	All	0.290	0.584	.001	36	view →
CHOL	DFS	Median	All	0.719	0.237	.001	32	view →
BLCA	DFS	Median	II,III,IV	0.489	0.256	.006	31	view →
COAD	DFS	Median	III,IV	0.519	0.322	.005	29	view →
THCA	OS	Tertile	III,IV	0.601	0.923	.005	27	view →
LUAD	DFS	Median	IV	0.329	0.647	.004	22	view →
OV	DFS	Median	IV	0.219	0.376	.023	18	view →
PAAD	DFS	Median	II,III,IV	0.523	0.347	.010	16	view →
GBM	DFS	Quartile	All	0.156	0.381	.001	15	view →
ACC	DFS	Tertile	II,III,IV	0.614	0.213	.018	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0035666–SKCM (OS)

Open the SKCM breakdown →