Clathrin-coated vesicle cargo loading

Across TCGA cell cohorts, RNA activity of the Clathrin-coated vesicle cargo loading pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AP3S1, POLB, and RREB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Clathrin-coated vesicle cargo loading activity versus AP3S1 in OESOPHAGUS (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	AP3S1 →	+2.480	+1.247	.001	.003	3	7
BREAST	POLB →	+0.897	+0.782	.001	.001	3	5
BONE	RREB1 →	+0.916	+1.351	.004	.003	3	5
OESOPHAGUS	GLO1 →	+1.171	+1.079	.001	.009	3	4
BREAST	MRPS27 →	+0.697	+0.852	.006	.008	3	4
PANCREAS	NDUFC1 →	+0.748	+1.645	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035652 vs AP3S1 — OESOPHAGUS

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