Ceramide transport

Across TCGA patient cohorts, RNA activity of the Ceramide transport pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABL2, TOMM22P5, and NDUFS8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ceramide transport activity versus ABL2 in PDAC (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ABL2 →	-0.391	-0.259	.001	.001	3	4
LUAD	TOMM22P5 →	+0.147	+0.118	.007	.009	3	4
CCRCC	NDUFS8 →	+0.184	+0.116	.006	.003	3	3
CCRCC	RNU6-494P →	+0.571	+0.144	.006	<.001	3	3
UCEC	HIPK3 →	-0.299	-0.158	.001	<.001	3	3
UCEC	CFAP97 →	-0.440	-0.153	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035627 vs ABL2 — PDAC

Explore this scatter interactively →