ER to Golgi ceramide transport

Across TCGA cell cohorts, RNA activity of the ER to Golgi ceramide transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCTD3, P2RY11, and MTMR14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCTD3 grouped by ER to Golgi ceramide transport-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KCTD3 →	-1.079	-1.311	<.001	.004	3	4
LUNG_NSCLC_LUSC	P2RY11 →	-1.850	-1.579	.006	<.001	3	4
BLOOD_Myeloma	MTMR14 →	+0.674	+1.585	.003	.008	2	5
LUNG_SCLC	ITPKB →	-1.847	-1.240	.003	.003	3	3
LUNG_NSCLC_LUSC	ANKMY1 →	-1.201	-0.991	.001	.002	3	3
OESOPHAGUS	BMPR1A →	-0.869	-0.408	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCTD3 by ER to Golgi ceramide transport activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →